Cell death in the thymus--it' s all a matter of contacts.

@article{Minter2003CellDI,
  title={Cell death in the thymus--it' s all a matter of contacts.},
  author={Lisa M Minter and Barbara A Osborne},
  journal={Seminars in immunology},
  year={2003},
  volume={15 3},
  pages={135-44}
}
Apoptosis, or programmed cell death, plays a critical role in shaping the T cell repertoire, deleting unproductive as well as potentially autoreactive T cells. Our understanding of how thymocyte apoptosis is regulated is continually evolving, as new essential modulators of this process are discovered. A conundrum that remains, however, is how signaling through essentially the same receptors and cascades evokes distinct biological responses: death by neglect, positive or negative selection. We… CONTINUE READING

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Apoptosis , or programmed cell death , plays a critical role in shaping the T cell repertoire , deleting unproductive as well as potentially autoreactive T cells .
Apoptosis , or programmed cell death , plays a critical role in shaping the T cell repertoire , deleting unproductive as well as potentially autoreactive T cells .
Apoptosis , or programmed cell death , plays a critical role in shaping the T cell repertoire , deleting unproductive as well as potentially autoreactive T cells .
Apoptosis , or programmed cell death , plays a critical role in shaping the T cell repertoire , deleting unproductive as well as potentially autoreactive T cells .
Apoptosis , or programmed cell death , plays a critical role in shaping the T cell repertoire , deleting unproductive as well as potentially autoreactive T cells .
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