Cell death in mammalian cell culture: molecular mechanisms and cell line engineering strategies

Abstract

Cell death is a fundamentally important problem in cell lines used by the biopharmaceutical industry. Environmental stress, which can result from nutrient depletion, by-product accumulation and chemical agents, activates through signalling cascades regulators that promote death. The best known key regulators of death process are the Bcl-2 family proteins… (More)
DOI: 10.1007/s10616-010-9274-0

4 Figures and Tables

Topics

  • Presentations referencing similar topics