Cell death in mammalian cell culture: molecular mechanisms and cell line engineering strategies


Cell death is a fundamentally important problem in cell lines used by the biopharmaceutical industry. Environmental stress, which can result from nutrient depletion, by-product accumulation and chemical agents, activates through signalling cascades regulators that promote death. The best known key regulators of death process are the Bcl-2 family proteins… (More)
DOI: 10.1007/s10616-010-9274-0

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