Cell death in fetal oocytes: many players for multiple pathways.

  title={Cell death in fetal oocytes: many players for multiple pathways.},
  author={Massimo De Felici and Anna Maria Lobascio and Francesca Gioia Klinger},
  volume={4 2},
We devised a short-term culture system allowing us to define novel characteristics of programmed cell death (PCD) of fetal oocytes and to underscore new aspects of this process. Mouse fetal oocytes cultured in conditions allowing meiotic progression underwent apoptotic degeneration as revealed by TUNEL staining, DNA ladder, Annexin V binding, PARP cleavage and, usually, caspase activation. TEM observations show, however, recurrent atypical apoptotic morphologies characterized by the absence of… CONTINUE READING


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