Cell death in early neural development: beyond the neurotrophic theory

@article{Rosa2000CellDI,
  title={Cell death in early neural development: beyond the neurotrophic theory},
  author={Enrique J. Rosa and Flora de Pablo},
  journal={Trends in Neurosciences},
  year={2000},
  volume={23},
  pages={454-458}
}
The important effect of cell death on projecting neurons during development is well established. However, this mainstream research might have diverted recognition of the cell death that occurs at earlier stages of neural development, affecting proliferating neural precursor cells and young neuroblasts. In this article, we briefly present observations supporting the occurrence of programmed cell death during early neural development in a regulated fashion that to some extent parallels the death… 
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Cell death in early neural life.
TLDR
Observations on cell death in the early, proliferating stages of vertebrate neural development in mice and complementary in vivo approaches in other vertebrates are covered.
Early neural cell death: dying to become neurons.
TLDR
Early neural PCD is addressed, which is distinct from neurotrophic death in differentiated neurons, and cell number control, removal of damaged or misspecified cells, and selection are the proposed roles early neural PCDs play during neural development.
Early neural cell death: numbers and cues from the developing neuroretina.
TLDR
The magnitude and the precise regulation of the early phases of cell death are fully comparable to the much better characterized neurotrophic cell death, so early neural cell death deserves a profound dedicated study to obtain an integrated understanding of the development of the retina and other parts of the vertebrate nervous system.
Cell death in the nervous system
TLDR
It is proposed that a broad neuroprotective role is the foundation for many of the observed functions of the insulin-related growth factors, whose therapeutical potential for nervous system disorders may be greater than currently accepted.
Regulation of neuronal survival and death by extracellular signals during development
  • A. Davies
  • Biology, Medicine
    The EMBO journal
  • 2003
TLDR
The established and emerging principles that modulate neuronal number in the developing nervous system are outlined.
Regulation of Neuronal Survival by Neurotrophins in the Developing Peripheral Nervous System
TLDR
This chapter focuses primarily on the neurotrophin family of neurotrophic factors and on neurons of the developing vertebrate peripheral nervous system where the control of neuronal survival is best understood.
Apoptosis of the cerebellar neurons.
TLDR
This review examines the existing evidence about the two waves of apoptotic cell death that affect the different types of cerebellar neurons in normal development and certain pathological conditions.
In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS
TLDR
Analysis of naturally occurring neuronal death (NOND) in vivo will offer a basis for parallel and future studies aiming to elucidate the mechanisms of pathologic neuronal loss occurring as the result of conditions such as neurodegenerative disorders, trauma or ischemia.
Apoptosis in the mammalian CNS: Lessons from animal models.
TLDR
A thorough analysis of naturally occurring neuronal death in vivo will offer a basis for parallel and future studies involving secondary neuronal loss such as those in neurodegenerative disorders, trauma or ischaemia.
Developmental Neuronal Elimination
TLDR
The functional involvement of microglia in the loss of neural cells during normal development is discussed and the mechanisms and cell signalling that underlie microglial regulation of PCD and elimination of dead cells are reviewed.
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