Cell death does not herald epithelial involution ("atrophy") in oral sub mucous fibrosis: a TEM study.

@article{Rajendran2004CellDD,
  title={Cell death does not herald epithelial involution ("atrophy") in oral sub mucous fibrosis: a TEM study.},
  author={Rashmika Rajendran and Sunil and S P Twinkle and T V Anikumar and John Annie},
  journal={Indian journal of dental research : official publication of Indian Society for Dental Research},
  year={2004},
  volume={15 1},
  pages={13-9}
}
The disease progression in oral submucous fibrosis (OSF) seems to be in a biphasic manner, along both fibroblastic and keratinocytic lineages. The epithelial malignancy is considered to be a sequel of connective tissue changes. "Atrophy" of epithelium makes it amenable to the effect of oral carcinogens. This concept looks rather simplistic in the light of the current understanding of epithelial cell biology. So the concept of epithelial "atrophy" needs redressal against the backdrop of recent… CONTINUE READING