Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts.

@article{Lu2014CellDC,
  title={Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts.},
  author={Chi-Cheng Lu and J. Yang and Jo-Hua Chiang and Mann-Jen Hour and Kuei-Li Lin and T. Lee and J. Chung},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1840 7},
  pages={
          2310-20
        }
}
BACKGROUND This investigation clearly clarified the synthesized and antimitotic compound, 2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone (HMJ-38), addressing its target and precise mechanism of action. We hypothesized that HMJ-38 might sensitize apoptotic death of human oral carcinoma CAL 27 cells in vitro and inhibit xenograft tumor growth in vivo. METHODS Cell viability was assessed utilizing MTT assay. HMJ-38-treated cells represented DNA fragmentation using agarose gel… Expand
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