Cell death by apoptosis during involution of the lactating breast in mice and rats.

  title={Cell death by apoptosis during involution of the lactating breast in mice and rats.},
  author={Neal I. Walker and R E Bennett and John F. R. Kerr},
  journal={The American journal of anatomy},
  volume={185 1},
The role of cell death in involution of lactating breast was investigated in mice and rats by light and electron microscopy. Apoptosis, recognized by sharply demarcated compaction of chromatin against the nuclear envelope and by shrinkage and budding of the whole cell to form membrane-bounded apoptotic bodies, was responsible for major loss of cells in both species. In the mouse, rapid involution during the first 2 days was associated with shedding of large numbers of apoptotic bodies derived… 
Involution of the sheep mammary gland
It was concluded that the mammary gland involutes by apoptosis, a process which allows deletion of cells without the loss of the basic architecture and the integrity of the epithelial lining of the gland.
Epithelial Cells Remove Apoptotic Epithelial Cells During Post-Lactation Involution of the Mouse Mammary Gland1
Abstract Following the cessation of lactation, the mammary gland undergoes a physiologic process of tissue remodeling called involution in which glandular structures are lost, leaving an adipose
Programmed cell death in bovine mammary tissue during lactation and involution
Cessation of milk removal causes mammary tissue involution, which in rodents is characterized by extensive tissue degeneration and loss of the majority of luminal epithelial cells by apoptosis. In
Regulation of apoptosis and functional activity in bovine mammary Acini
The results indicate that bovine mammary cells undergo apoptotic process after the cessation of milking and that TNFα may trigger apoptosis in lactating bovines mammary acini.
Roles of Fas and Fas ligand during mammary gland remodeling.
The results suggest that the Fas-FasL interaction plays an important role in the normal remodeling of mammary tissue and this autocrine induction of apoptosis may prevent accumulation of cells with mutations and subsequent neoplastic development.
Apoptotic cell death and tissue remodelling during mouse mammary gland involution.
During post-lactational mammary gland involution, the bulk of mammary epithelium dies and is reabsorbed. This massive cell death and tissue restructuring was found to be accompanied by a specific
Involvement of the TNF-α system and the Fas system in the induction of apoptosis of mouse mammary glands after weaning
TNF-α and anti-Fas antibody directly killed more than 80% of mammary cells from p53 knockout mice in vitro within 24 h in the presence of actinomycin D, supporting the hypothesis that Fas and/or TNF- α are involved in the induction of apoptosis of mouse mammary glands.
Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of α-lactalbumin
The results suggest that HAMLET can mediate apoptotic cell death in mammary gland tissue and no effects were observed when mammary glands were exposed to native a-lactalbumin or fatty acid alone.
Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways.
The data support the hypothesis that there are at least two distinct phases of involution: an initial phase, characterized by induction of the apoptosis-associated genes SGP-2 and ICE and apoptosis of fully differentiated mammary epithelial cells without visible degradation of the extracellular matrix, and a second phase, characterize by extrace cellular matrix remodeling and altered mesenchymal-epithelial interactions, followed by apoptotic cells that are losing differentiated functions.


Ultrastructure of the rat pancreas after experimental duct ligation. I. The role of apoptosis and intraepithelial macrophages in acinar cell deletion.
  • N. Walker
  • Biology
    The American journal of pathology
  • 1987
After ligation of the rat pancreas, acinar cells disappeared from the distal gland within 5 days, and this distinctive form of cell death was characterized by cellular condensation followed by surface budding to produce membrane-bounded apoptotic bodies.
Cell death and cell proliferation during atrophy of the rat parotid gland induced by duct obstruction
Rat parotid gland atrophy after unilateral duct ligation was studied by light and electron microscopy and compensatory hyperplasia, involving proliferation of duct and acinar cells, was demonstrated in the contralateral glands.
Hormonal control of apoptosis in hamster uterine luminal epithelium.
Because of the periodic, hormonally regulated occurrence of extensive apoptosis in the hamster uterine epithelium during the estrous cycle, this system is well-suited for further investigations on the ultrastructural alterations that occur in cells undergoing apoptosis.
An ultrastructural study of normal human mammary epithelial cells in culture.
The regular occurrence of normal human mammary cells in breast fluids during the terminal phases of lactation suggests that their separation is a part of normal breast involution.
Melanosis coli. A consequence of anthraquinone-induced apoptosis of colonic epithelial cells.
Examination of colonic biopsies from patients with melanosis coli shows increased numbers of apoptotic bodies in the surface epithelium and lamina propria, suggesting implication of the same cellular processes in the formation of the pigment in man.
Apoptosis: Its nature and implications for dermatopathology
Apoptosis is a distinctive mode of cell death with characteristic morphologic features which serves as a balance to mitosis in regulating the size of animal tissues and is a feature of such diverse processes as deletion of phylogenetic vestiges during normal embryonic development, involution of endocrine-dependent organs after withdrawal of trophic hormones, and therapeutically induced regression of neoplasms.
Mechanism of deletion of endothelial cells during regression of the corpus luteum.
Experimental findings were consistent with the hypothesis that cessation or reduction of flow of blood along capillaries plays an etiologic rule in endothelial cell deletion.