Cell death assays for drug discovery

  title={Cell death assays for drug discovery},
  author={Oliver Kepp and Lorenzo Galluzzi and Marta Lipinski and Junying Yuan and Guido Kroemer},
  journal={Nature Reviews Drug Discovery},
Cell death has an important role in many human diseases, and strategies aimed at modulating the associated pathways have been successfully applied to treat various disorders. Indeed, several clinically promising cytotoxic and cytoprotective agents with potential applications in cancer, ischaemic and neurodegenerative diseases have recently been identified by high-throughput screening (HTS), based on appropriate cell death assays. Given that different cell death modalities may be dysregulated in… CONTINUE READING
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