Cell death and learning impairment in mice caused by in vitro modified pro-NGF can be related to its increased oxidative modifications in Alzheimer disease.

@article{Kichev2009CellDA,
  title={Cell death and learning impairment in mice caused by in vitro modified pro-NGF can be related to its increased oxidative modifications in Alzheimer disease.},
  author={Anton Kichev and Ekaterina V. Ilieva and Gerard Pi{\~n}ol-Ripoll and Petar Podlesniy and Isidro Ferrer and Manuel Portero-Ot{\'i}n and Reinald Pamplona and Carme Espinet},
  journal={The American journal of pathology},
  year={2009},
  volume={175 6},
  pages={2574-85}
}
Pro-nerve growth factor (pro-NGF) is expressed at increased levels in Alzheimer's disease (AD)-affected brains and is able to induce cell death in cultures; however, the reasons for these phenomena remain elusive. Here we show that pro-NGF in human AD-affected hippocampus and entorhinal cortex is modified by advanced glycation and lipoxidation end-products in a stage-dependent manner. These modifications block pro-NGF processing to mature NGF, thus making the proneurotrophin especially… CONTINUE READING
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