Cell death and immunity: The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

Abstract

Granule exocytosis is the main pathway for the immune elimination of virus-infected cells and tumour cells by cytotoxic T lymphocytes and natural killer cells. After target-cell recognition, release of the cytotoxic granule contents into the immunological synapse formed between the killer cell and its target induces apoptosis. The granules contain two… (More)
DOI: 10.1038/nri1083

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