Cell death and control of cell survival in the oligodendrocyte lineage
@article{Barres1992CellDA, title={Cell death and control of cell survival in the oligodendrocyte lineage}, author={Barbara A. Barres and I. K. Hart and H S Coles and Julia F. Burne and J T Voyvodic and William D. Richardson and M. C. Raff}, journal={Cell}, year={1992}, volume={70}, pages={31-46} }
1,299 Citations
Cell death in the oligodendrocyte lineage.
- BiologyJournal of neurobiology
- 1992
The results suggest that competition for limiting amounts of survival factors is not confined to developing neurons, and raise the possibility that a similar mechanism may be responsible for some naturally occurring cell deaths in nonneural tissues.
Growth factor stimulation triggers apoptotic cell death in mature oligodendrocytes
- BiologyJournal of neuroscience research
- 1996
Rat oligodendrocytes expressed the immediate response gene c‐fos and the cell cycle‐associated protein proliferating cell nuclear antigen, but failed to divide and ultimately underwent cell death by apoptosis, consistent with the emerging view that mitosis and apoptosis are closely linked phenomena.
Programmed cell death and the control of cell survival: lessons from the nervous system.
- BiologyScience
- 1993
This neurotrophic strategy for the regulation of neuronal numbers may be only one example of a general mechanism that helps to regulate the numbers of many other vertebrate cell types, which also require signals from other cells to survive.
The schwann cell precursor and its fate: A study of cell death and differentiation during gliogenesis in rat embryonic nerves
- BiologyNeuron
- 1994
Control of Oligodendrocyte Precursor Proliferation Mediated by Density-Dependent Cell Cycle Protein Expression
- BiologyDevelopmental Neuroscience
- 2001
A density-dependent reduction in the proliferation of oligodendrocyte precursors is demonstrated and this inhibition of proliferation is correlated with increases in expression levels of the cell cycle inhibitor p27Kip1, reductions in the expression of cyclin A and changes in the relative phosphorylation levels of Rb.
Regulation of oligodendrocyte development
- BiologyMolecular Neurobiology
- 2007
The major factors that regulate three distinct stages in the development of the oligodendrocyte lineage are discussed: the initial induction of oligodendedrocytes progenitors, the regulation of expansion and dispersion of the committed precursor cell population.
Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor.
- BiologyDevelopment
- 1993
It is shown that normal cell death is found in both the nephrogenic region and medullary papilla of the developing rat kidney and, in each of these areas, it follows a distinct developmental time course, indicating large-scale death is a normal feature of kidney development.
Cell number control and timing in animal development: the oligodendrocyte cell lineage.
- BiologyThe International journal of developmental biology
- 1998
Our studies of oligodendrocyte development in the rodent optic nerve provide clues as to how cell numbers and the timing of differentiation may be controlled during mammalian development. Both cell…
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It is shown that although PDGF does not stimulate newly formed oligodendrocytes to synthesize DNA, it induces an increase in cytosolic Ca2+ in these cells, and the most parsimonious explanation for these results is that O-2A progenitor cells become mitotically unresponsive to PDGF because the intracellular signaling pathways are blocked downstream from the receptor and some of the early events that are triggered by receptor activation are blocked.
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Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil
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It is found that platelet-derived growth factor mimics the effects of type-1 astrocytes on O-2A progenitor cells, and antibodies to PDGF block the effects.
PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage.
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- 1989
Radiolabelled PDGF is used to show that O-2A progenitor cells have PDGF receptors, suggesting that these cells respond directly to PDGF, which is similar to the type A PDGF receptor previously described on human fibroblasts.