Cell death and control of cell survival in the oligodendrocyte lineage

@article{Barres1992CellDA,
  title={Cell death and control of cell survival in the oligodendrocyte lineage},
  author={Barbara A. Barres and I. K. Hart and H S Coles and Julia F. Burne and J T Voyvodic and William D. Richardson and M. C. Raff},
  journal={Cell},
  year={1992},
  volume={70},
  pages={31-46}
}
Dead cells are observed in many developing animal tissues, but the causes of these normal cell deaths are mostly unknown. We show that about 50% of oligodendrocytes normally die in the developing rat optic nerve, apparently as a result of a competition for limiting amounts of survival signals. Both platelet-derived growth factor and insulin-like growth factors are survival factors for newly formed oligodendrocytes and their precursors in culture. Increasing platelet-derived growth factor in the… Expand
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Our studies of oligodendrocyte development in the rodent optic nerve provide clues as to how cell numbers and the timing of differentiation may be controlled during mammalian development. Both cellExpand
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