Cell death and control of cell survival in the oligodendrocyte lineage

@article{Barres1992CellDA,
  title={Cell death and control of cell survival in the oligodendrocyte lineage},
  author={Barbara A. Barres and I. K. Hart and H S Coles and Julia F. Burne and J T Voyvodic and William D. Richardson and M. C. Raff},
  journal={Cell},
  year={1992},
  volume={70},
  pages={31-46}
}
Dead cells are observed in many developing animal tissues, but the causes of these normal cell deaths are mostly unknown. We show that about 50% of oligodendrocytes normally die in the developing rat optic nerve, apparently as a result of a competition for limiting amounts of survival signals. Both platelet-derived growth factor and insulin-like growth factors are survival factors for newly formed oligodendrocytes and their precursors in culture. Increasing platelet-derived growth factor in the… Expand
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Cell death in the oligodendrocyte lineage.
TLDR
The results suggest that competition for limiting amounts of survival factors is not confined to developing neurons, and raise the possibility that a similar mechanism may be responsible for some naturally occurring cell deaths in nonneural tissues. Expand
Growth factor stimulation triggers apoptotic cell death in mature oligodendrocytes
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Rat oligodendrocytes expressed the immediate response gene c‐fos and the cell cycle‐associated protein proliferating cell nuclear antigen, but failed to divide and ultimately underwent cell death by apoptosis, consistent with the emerging view that mitosis and apoptosis are closely linked phenomena. Expand
Oligodendrocyte Population Dynamics and the Role of PDGF In Vivo
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Experiments with transgenic mice show that platelet-derived growth factor (PDGF) drives progenitor cell division and suggest that slowing of and exit from the cycle reflects a decline in PDGF signaling. Expand
Programmed cell death and the control of cell survival: lessons from the nervous system.
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This neurotrophic strategy for the regulation of neuronal numbers may be only one example of a general mechanism that helps to regulate the numbers of many other vertebrate cell types, which also require signals from other cells to survive. Expand
The schwann cell precursor and its fate: A study of cell death and differentiation during gliogenesis in rat embryonic nerves
TLDR
Evidence that the survival of Schwann cell precursors is regulated by neurons is provided and basic fibroblast growth factor is identified as a potential key regulator of apoptosis in Schwann Cell precursor and of precursor to Schwanncell conversion are identified. Expand
Does oligodendrocyte survival depend on axons?
TLDR
The results strongly suggest that oligodendrocyte survival depends upon the presence of axons and support the hypothesis that a competition for axon-dependent survival signals normally helps adjust the number of oligodendedrocytes to the numberof axons that require myelination. Expand
Control of Oligodendrocyte Precursor Proliferation Mediated by Density-Dependent Cell Cycle Protein Expression
TLDR
A density-dependent reduction in the proliferation of oligodendrocyte precursors is demonstrated and this inhibition of proliferation is correlated with increases in expression levels of the cell cycle inhibitor p27Kip1, reductions in the expression of cyclin A and changes in the relative phosphorylation levels of Rb. Expand
Regulation of oligodendrocyte development
TLDR
The major factors that regulate three distinct stages in the development of the oligodendrocyte lineage are discussed: the initial induction of oligodendedrocytes progenitors, the regulation of expansion and dispersion of the committed precursor cell population. Expand
Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor.
TLDR
It is shown that normal cell death is found in both the nephrogenic region and medullary papilla of the developing rat kidney and, in each of these areas, it follows a distinct developmental time course, indicating large-scale death is a normal feature of kidney development. Expand
Cell number control and timing in animal development: the oligodendrocyte cell lineage.
Our studies of oligodendrocyte development in the rodent optic nerve provide clues as to how cell numbers and the timing of differentiation may be controlled during mammalian development. Both cell… Expand
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References

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It is shown that platelet-derived growth factor (PDGF) can replace type-1-astrocyte-conditioned medium in restoring the normal timing of oligodendrocytes differentiation in vitro and that anti-PDGF antibodies inhibit this property of the appropriately conditioned medium. Expand
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TLDR
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TLDR
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TLDR
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