Cell death and control of cell survival in the oligodendrocyte lineage

@article{Barres1992CellDA,
  title={Cell death and control of cell survival in the oligodendrocyte lineage},
  author={Barbara A. Barres and I. K. Hart and H S Coles and Julia F. Burne and J T Voyvodic and William D. Richardson and M. C. Raff},
  journal={Cell},
  year={1992},
  volume={70},
  pages={31-46}
}

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References

SHOWING 1-10 OF 158 REFERENCES

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

It is shown that platelet-derived growth factor (PDGF) can replace type-1-astrocyte-conditioned medium in restoring the normal timing of oligodendrocytes differentiation in vitro and that anti-PDGF antibodies inhibit this property of the appropriately conditioned medium.

Differentiation of a bipotential glial progenitor cell in single cell microculture

It is shown that 0-2A progenitor cells can differentiate into type-2 astrocytes or oligodendroCytes when grown as isolated cells in microculture, indicating that differentiation along either glial pathway in vitro does not require signals from other CNS cells, apart from the signals provided by components of the culture medium.

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

It is shown that the death of haemopoietic precursor cells on withdrawal of the relevant CSF is due to active cell death5, or apoptosis, indicating that CSFs promote cell survival by suppression of the process of apoptosis.

Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell.

This work has found that the O‐2A progenitors are stimulated to divide in culture by purified populations of type 1 astrocytes, another glial cell‐type found in the rat optic nerve.

Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit

The jimpy model may prove to be a valuable tool in delineating a role for normal neuroglial cell death during the development of the nervous system and presents a simple explanation for the gross deficits of myelin in jIMpy animals.

PDGF and intracellular signaling in the timing of oligodendrocyte differentiation

It is shown that although PDGF does not stimulate newly formed oligodendrocytes to synthesize DNA, it induces an increase in cytosolic Ca2+ in these cells, and the most parsimonious explanation for these results is that O-2A progenitor cells become mitotically unresponsive to PDGF because the intracellular signaling pathways are blocked downstream from the receptor and some of the early events that are triggered by receptor activation are blocked.

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

It is found that platelet-derived growth factor mimics the effects of type-1 astrocytes on O-2A progenitor cells, and antibodies to PDGF block the effects.
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