Cell death and axon regeneration of Purkinje cells after axotomy: Challenges of classical hypotheses of axon regeneration

@article{Dusart2005CellDA,
  title={Cell death and axon regeneration of Purkinje cells after axotomy: Challenges of classical hypotheses of axon regeneration},
  author={Isabelle Dusart and Abdel M Ghoumari and Rosine Wehrl{\'e} and M P Morel and Constantino Sotelo},
  journal={Brain Research Reviews},
  year={2005},
  volume={49},
  pages={300-316}
}
Although adult mammalian neurons are able to regenerate their axons in the peripheral nervous system under certain conditions, they are not able to do it in the central nervous system. The environment surrounding the severed axons appears to be a key factor for axon regeneration. Many studies aiming to enhance axon regeneration in the CNS of adult mammals have successfully manipulated this environment by adding growth permissive molecules and/or neutralizing growth inhibitory molecules. In both… CONTINUE READING

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