Cell death after exposure to subarachnoid hemolysate correlates inversely with expression of CuZn-superoxide dismutase.

@article{Matz2000CellDA,
  title={Cell death after exposure to subarachnoid hemolysate correlates inversely with expression of CuZn-superoxide dismutase.},
  author={Paul G. Matz and Jean Christophe Copin and Pak Hoo Chan},
  journal={Stroke},
  year={2000},
  volume={31 10},
  pages={2450-9}
}
BACKGROUND AND PURPOSE Subarachnoid hemolysate (SAH) has been associated with oxidative brain injury, cell death, and apoptosis. We hypothesized that over-expression of CuZn-superoxide dismutase (CuZn-SOD) would protect against injury after SAH, whereas reduction of its expression would exacerbate injury. METHODS Saline (n=16) or hemolysate (n=50) was injected into transgenic mice overexpressing CuZn-SOD (SOD1-Tg), CuZn-SOD heterozygous knockout mutants (SOD1+/-), and wild-type littermates… CONTINUE READING
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