Cell death: Delicate decisions

GSK3 http://ca.expasy.org/uniprot/ P49841 The anti-apoptotic BCL2-family member MCL1 can be induced by a number of growth factors and promote cell survival. However, how growth factors maintain MCL1 levels to prevent apoptosis has been unclear. Maurer et al. now report that the control of MCL1 stability by glycogen synthase kinase-3 (GSK3) is an important… CONTINUE READING