Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma

@article{Kunkeaw2013CellDR,
  title={Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma},
  author={Nawapol Kunkeaw and So Hyeon Jeon and K Lee and Betty H. Johnson and Suebpong Tanasanvimon and Milind M. Javle and Chawalit Pairojkul and Yaovalux Chamgramol and Wipaporn Wongfieng and Bendi Gong and Chanwit Leelayuwat and Youn Soo Lee},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={3722-3731}
}
We have recently identified nc886 (pre-miR-886 or vtRNA2-1) as a novel type of non-coding RNA that inhibits activation of protein kinase R (PKR). PKR’s pro-apoptotic role through eukaryotic initiation factor 2 α (eIF2α) phosphorylation is well established in the host defense against viral infection. Paradoxically, some cancer patients have elevated PKR activity; however, its cause and consequence are not understood. Initially, we evaluated the expression of nc886, PKR and eIF2α in non-malignant… CONTINUE READING
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