Corpus ID: 33423298

Cell-cycle specificity and therapeutic effectiveness of cytostatic agents.

@article{Putten1972CellcycleSA,
  title={Cell-cycle specificity and therapeutic effectiveness of cytostatic agents.},
  author={L. V. van Putten and P. Lelieveld and L. Kram-Idsenga},
  journal={Cancer chemotherapy reports},
  year={1972},
  volume={56 6},
  pages={
          691-700
        }
}

Topics from this paper

Analysis of the effect of prior therapy on progenitor cell yield: use of a chemotherapy scoring system
A quantitative analysis of peripheral blood stem cell (PBSC) yield, measuring absolute numbers of CD34+ cells × 106/kg and CFU‐C × 104/kg was performed in 74 consecutive patients. The interval orExpand
The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy
TLDR
Of special interest is the fact that a single administration of low-dose cyclophosphamide is able to selectively suppress regulatory T cells (Tregs) and can be used to counteract immunosuppression in cancer. Expand
Modulation of 5-Fluorouracil-induced Toxicity in Mice with Interferon or with the Interferon Inducer , Po ly inos in icPo lycyt idy l i c Acid 1
Partially purified preparations of mouse interferon, administered during the 2-day period following the administration of a toxic dose of 5-fluorouracil (FUra), yielded significant protection fromExpand
10. Krebs-Chemotherapie bei soliden Tumoren —heutiger Stand
  • R. Gross
  • Medicine, Physics
  • Langenbecks Archiv für Chirurgie
  • 2005
TLDR
In both the experimental field (literature and the author's own examinations) and in clinical experience (still limited), partial synchronization has proved clearly superior to “blind” polychemotherapy. Expand
Bone marrow CD34+ cell count is predictive for adequate peripheral progenitor cell collection.
TLDR
In this setting, a BM concentration of CD34+ cells lower than 66 microL(-1) was associated with a higher probability of inadequate collection, particularly in MM patients. Expand
Changing metastatic patterns of a transplantable rat osteosarcoma
TLDR
The influence of survival time, sex, age of donor and recipient animals at time of transplantation, on the development of metastasis in lungs, kidneys, lymph nodes and liver was investigated and metastatic behavior patterns in 303 untreated Sprague-Dawley rats bearing a transplantable cerium-144-induced osteosarcoma is described. Expand
Comparative effects of ASTA Z 7557 (INN mafosfamide) and cyclophosphamide on hematopoiesis in mice
TLDR
Results indicate quantitative rather than qualitative differences between the marrow toxicities of ASTA Z 7557 and Cy in mice, which could be due to different pharmacokinetic properties of the agents. Expand
Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays
TLDR
Three methods of measuring cell proliferation, viz., cellular 3H-thymidine uptake, counting of cells in suspension, and counting of colonies of cells grown in agar contained in glass capillaries, were compared by studying cell growth kinetics using the L 1210 cell line to be most suitable and methodologically most advantageous. Expand
Dose-response curves after in vivo experimental chemotherapy: Influence of rouze of administration on biological outcomes
TLDR
Four examples are taken from the literature, in which such considerat ions influenced the quanti tat ive and qualitative interpretat ion of biological response measured as a function of adminis tered dose. Expand
Effect of cumulative etoposide doses on the outcome of autologous peripheral-blood progenitor-cell transplantation for lymphoma
TLDR
Pre-transplant cumulative doses of etoposide >350 mg/m2 and previous administration of procarbazine were found to be independent prognostic factors for TRM. Expand
...
1
2
3
4
5
...