Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.


Rare cells with the properties of stem cells are integral to the development and perpetuation of leukaemias. A defining characteristic of stem cells is their capacity to self-renew, which is markedly extended in leukaemia stem cells. The underlying molecular mechanisms, however, are largely unknown. Here we demonstrate that expression of the cell-cycle… (More)
DOI: 10.1038/nature07618


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