Cell cycle-related kinase: a novel candidate oncogene in human glioblastoma.

  title={Cell cycle-related kinase: a novel candidate oncogene in human glioblastoma.},
  author={Samuel Sai-ming Ng and Y B Cheung and Xiao-meng An and Yang Chao Chen and Ming Li and Gloria Hoi-Yee Li and William Ka Lung Cheung and Johnny Sze and Lihui Lai and Y. N. Peng and Harry Hua Xiang Xia and Benjamin Chun-yu Wong and Suet-yi Leung and Dan Xie and Ming-liang He and Hsiang-fu Kung and Marie C. M. Lin},
  journal={Journal of the National Cancer Institute},
  volume={99 12},
BACKGROUND Median survival for patients with glioblastoma multiforme, the most aggressive glioma, is only 12-15 months, despite multimodal treatment that includes surgery, chemotherapy, and radiotherapy. Thus, identification of genes that control the progression of glioblastoma multiforme is crucial for devising new therapies. We investigated the involvement of cell cycle-related kinase (CCRK), a novel protein kinase that is homologous to cyclin-dependent kinase 7, in glioblastoma multiforme… CONTINUE READING