Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex.


Germ-line alterations in BRCA1 are associated with an increased susceptibility to breast and ovarian cancer. The BRCA1 protein has been implicated in multiple cellular functions. We have recently demonstrated that BRCA1 reduces acetyl-CoA-carboxylase alpha (ACCA) activity through its phospho-dependent binding to ACCA, and further established that the… (More)
DOI: 10.1016/j.bbrc.2008.11.090


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