Cell cycle regulation of folate‐mediated one‐carbon metabolism

  title={Cell cycle regulation of folate‐mediated one‐carbon metabolism},
  author={Xuan Lan and Martha S. Field and Patrick J Stover},
  journal={Wiley Interdisciplinary Reviews: Systems Biology and Medicine},
  • X. LanM. FieldP. Stover
  • Published 11 June 2018
  • Biology
  • Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Folate‐mediated one‐carbon metabolism (FOCM) comprises a network of interconnected folate‐dependent metabolic pathways responsible for serine and glycine interconversion, de novo purine synthesis, de novo thymidylate synthesis and homocysteine remethylation to methionine. These pathways are compartmentalized in the cytosol, nucleus and mitochondria. Individual enzymes within the FOCM network compete for folate cofactors because intracellular folate concentrations are limiting. Although there… 

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Folate-mediated one-carbon metabolism.

Compartmentalization of Mammalian folate-mediated one-carbon metabolism.

Sequencing of the human and other mammalian genomes has facilitated identification of the enzymes that participate in this intercompartmental one-carbon metabolism, and animal models are beginning to clarify the roles of the cytoplasmic and mitochondrial isozymes of these enzymes.

New perspectives on folate catabolism.

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Regulation of mammalian nucleotide metabolism and biosynthesis

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Regulation of folate and one-carbon metabolism in mammalian cells. III. Role of mitochondrial folylpoly-gamma-glutamate synthetase.

Wild-type Chinese hamster ovary cells and CHO cell transfectants expressing human folylpoly-gamma-glutamate synthetase (FPGS) activity contain mitochondrial FPGS activity of higher specific activity than the cytosolic isozyme, which is required for folate accumulation by mitochondria.

Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protect de Novo Thymidylate Biosynthesis during Folate Deficiency*

It is demonstrated that methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), an enzyme that generates methylenetic units from formate, ATP, and NADPH, functions in the nucleus to support de novo thymidylate biosynthesis.

Mammalian Pyrimidine Biosynthesis: Fresh Insights into an Ancient Pathway*

This review focuses on the structure and regulation of the pyrimidine biosynthetic complexes and the interplay of the diverse control mechanisms operative in mammalian cells.

Cell Cycle-dependent Regulation of Pyrimidine Biosynthesis*

The cell cycle-dependent regulation of pyrimidine biosynthesis results from the sequential phosphorylation and dephosphorylation of CAD under the control of two important signaling cascades.

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

Collectively, the data provide strong evidence for the formation of a multi-enzyme complex, the “purinosome,” to carry out de novo purine biosynthesis in cells.