Cell cycle regulation of folate‐mediated one‐carbon metabolism

@article{Lan2018CellCR,
  title={Cell cycle regulation of folate‐mediated one‐carbon metabolism},
  author={Xuan Lan and Martha S. Field and Patrick J Stover},
  journal={Wiley Interdisciplinary Reviews: Systems Biology and Medicine},
  year={2018},
  volume={10}
}
  • X. LanM. FieldP. Stover
  • Published 11 June 2018
  • Biology
  • Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Folate‐mediated one‐carbon metabolism (FOCM) comprises a network of interconnected folate‐dependent metabolic pathways responsible for serine and glycine interconversion, de novo purine synthesis, de novo thymidylate synthesis and homocysteine remethylation to methionine. These pathways are compartmentalized in the cytosol, nucleus and mitochondria. Individual enzymes within the FOCM network compete for folate cofactors because intracellular folate concentrations are limiting. Although there… 

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