Cell cycle regulation in response to DNA damage in mammalian cells: A historical perspective

@article{Murnane1995CellCR,
  title={Cell cycle regulation in response to DNA damage in mammalian cells: A historical perspective},
  author={John P. Murnane},
  journal={Cancer and Metastasis Reviews},
  year={1995},
  volume={14},
  pages={253-254}
}
Cell cycle delay has long been known to occur in mammalian cells after exposure to DNA-damaging agents. It has been hypothesized that the function of this delay is to provide additional time for repair of DNA before the cell enters critical periods of the cell cycle, such as DNA synthesis in S phase or chromosome condensation in G2 phase. Recent evidence that p53 protein is involved in the delay in G1 in response to ionizing radiation has heightened interest in the importance of cell cycle… CONTINUE READING

From This Paper

Topics from this paper.
22 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…