Cell cycle regulation by the B-Myb transcription factor

  title={Cell cycle regulation by the B-Myb transcription factor},
  author={Manel Joaquin and Roger J. Watson},
  journal={Cellular and Molecular Life Sciences CMLS},
The expression of genes required for progression through the cell cycle is highly modulated through a regulatory axis containing the E2F transcription factor and retinoblastoma tumour suppressor protein families. One of the genes regulated through this mechanism encodes the B-Myb transcription factor, which has been shown to be critically required for early embryonal development in the mouse. Transcriptional activity of B-Myb is substantially enhanced in S phase through modification by cyclin A… CONTINUE READING