Cell cycle regulation by long non-coding RNAs

  title={Cell cycle regulation by long non-coding RNAs},
  author={Masatoshi Kitagawa and Kyoko Kitagawa and Yojiro Kotake and Hiroyuki Niida and Tatsuya Ohhata},
  booktitle={Cellular and Molecular Life Sciences},
The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins, CDKs, CDK inhibitors, pRB, and p53. These lncRNAs act as epigenetic regulators, transcription factor regulators, post-transcription regulators, and protein scaffolds. These cell cycle-regulated… CONTINUE READING


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