Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38.

  title={Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38.},
  author={G{\"o}ran Brattsand and Ulrica Marklund and Karin Nylander and G{\"o}ran Roos and Martin Gullberg},
  journal={European journal of biochemistry},
  volume={220 2},
Oncoprotein 18 (Op18) has been independently identified due to its increased phosphorylation in response to external signals and its up-regulated expression in acute leukemia. We have identified two serine residues of Op18 that are phosphorylated after triggering by the T cell antigen receptor. One of these residues, Ser25, was shown to be a likely substrate for the mitogen-activated protein (MAP) kinase, while the other residue, Ser16, was shown to be phosphorylated in response to increased… CONTINUE READING
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