Cell cycle-regulated degradation of tmRNA is controlled by RNase R and SmpB.

@article{Hong2005CellCD,
  title={Cell cycle-regulated degradation of tmRNA is controlled by RNase R and SmpB.},
  author={Sue-Jean Hong and Quyen-Anh Tran and Kenneth C Keiler},
  journal={Molecular microbiology},
  year={2005},
  volume={57 2},
  pages={
          565-75
        }
}
The production and removal of regulatory RNAs must be controlled to ensure proper physiological responses. SsrA RNA (tmRNA), a regulatory RNA conserved in all bacteria, is cell cycle regulated and is important for control of cell cycle progression in Caulobacter crescentus. We report that RNase R, a highly conserved 3' to 5' exoribonuclease, is required for the selective degradation of SsrA RNA in stalked cells. Purified RNase R degrades SsrA RNA in vitro, and is kinetically competent to… CONTINUE READING
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