Cell cycle population effects in perturbation studies

  title={Cell cycle population effects in perturbation studies},
  author={Eoghan O'Duibhir and Philip Lijnzaad and Joris J. Benschop and Tineke L. Lenstra and Dik van Leenen and Marian J. A. Groot Koerkamp and Thanasis Margaritis and Mariel O. Brok and Patrick Kemmeren and Frank Cp Holstege},
  booktitle={Molecular systems biology},
Growth condition perturbation or gene function disruption are commonly used strategies to study cellular systems. Although it is widely appreciated that such experiments may involve indirect effects, these frequently remain uncharacterized. Here, analysis of functionally unrelated Saccharyomyces cerevisiae deletion strains reveals a common gene expression signature. One property shared by these strains is slower growth, with increased presence of the signature in more slowly growing strains… CONTINUE READING
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Comprehensive identification of cell a 2014 The Authors

  • PT Spellman, G Sherlock, +6 authors B Futcher
  • 1998
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