Cell-cycle initiation in yeast follows first-order kinetics

@article{Shilo1976CellcycleII,
  title={Cell-cycle initiation in yeast follows first-order kinetics},
  author={Ben-Zion Shilo and V. V. Shilo and Giora Simchen},
  journal={Nature},
  year={1976},
  volume={264},
  pages={767-770}
}
THE mitotic cell cycle is an orderly sequence of events, leading to cell division. In mammalian cell lines, a single event in the cycle exhibits first-order kinetics1, apparently dividing a cell's lifespan into a probabilistic state and a deterministic phase, termed A and B respectively. This rate-limiting event occurs during the G1 phase2,3, but its relation to the resting state and to the initiation of the cell cycle is unclear. In this paper we suggest that a probabilistic event exists in… CONTINUE READING

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