Cell cycle expression of estrogen receptors determined by image analysis on human breast cancer cellsin vitro andin vivo

@article{Rostagno1996CellCE,
  title={Cell cycle expression of estrogen receptors determined by image analysis on human breast cancer cellsin vitro andin vivo},
  author={Philippe Rostagno and Jonathan Moll and Isabelle Birtwisle-Peyrottes and Francette Ettore and Cyril Caldani},
  journal={Breast Cancer Research and Treatment},
  year={1996},
  volume={39},
  pages={147-154}
}
We have investigated, by image analysis, the cell cycle expression of estrogen receptors (ER) on MCF-7 cell line and on MCF-7 xenografts. The results demonstrate,in vitro as well asin vivo, an increase of ER concentration during the G0/G1-phase, followed by a decrease during the S-phase until the late S-phase where a rapid increase was noted. These results confirm that estrogens are involved in the DNA synthesis since ER is expressedin vivo at a maximal level in the late G1. In presence of… CONTINUE READING

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