Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle.

  title={Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle.},
  author={Brian T. Zafonte and James Hulit and Derek F. Amanatullah and Chris Albanese and C. Wang and E M Rosen and Anne T. Reutens and Joseph A. Sparano and Michael P Lisanti and Richard G. Pestell},
  journal={Frontiers in bioscience : a journal and virtual library},
  • B. ZafonteJ. Hulit R. Pestell
  • Published 1 December 2000
  • Biology, Chemistry, Medicine
  • Frontiers in bioscience : a journal and virtual library
Breast cancer is the most commonly diagnosed cancer in American women. The underlying mechanisms that cause aberrant cell proliferation and tumor growth involve conserved pathways, which include components of the cell cycle machinery. Proto-oncogenes, growth factors, and steroids have been implicated in the pathogenesis of breast cancer. Surgery, local irradiation, and chemotherapy have been the mainstay of treatment for early and advanced stage disease. Potential targets for selective breast… 

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