Cell-cycle dynamics of chromosomal organisation at single-cell resolution

  title={Cell-cycle dynamics of chromosomal organisation at single-cell resolution},
  author={Takashi Nagano and Yaniv Lubling and Csilla V{\'a}rnai and Carmel Dudley and Wing Tat Leung and Yael Baran and Netta Mendelson-Cohen and Steven W Wingett and Peter Fraser and Amos Tanay},
Chromosomes in proliferating metazoan cells undergo marked structural metamorphoses every cell cycle, alternating between highly condensed mitotic structures that facilitate chromosome segregation, and decondensed interphase structures that accommodate transcription, gene silencing and DNA replication. Here we use single-cell Hi-C (high-resolution chromosome conformation capture) analysis to study chromosome conformations in thousands of individual cells, and discover a continuum of cis… CONTINUE READING
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