Cell cycle dynamics of NG2 cells in the postnatal and ageing brain.

  title={Cell cycle dynamics of NG2 cells in the postnatal and ageing brain.},
  author={Konstantina Psachoulia and Françoise Jamen and Kaylene Young and William D Richardson},
  journal={Neuron glia biology},
  volume={5 3-4},
Oligodendrocyte precursors (OLPs or 'NG2 cells') are abundant in the adult mouse brain, where they continue to proliferate and generate new myelinating oligodendrocytes. By cumulative BrdU labelling, we estimated the cell cycle time TC and the proportion of NG2 cells that is actively cycling (the growth fraction) at approximately postnatal day 6 (P6), P60, P240 and P540. In the corpus callosum, TC increased from <2 days at P6 to approximately 9 days at P60 to approximately 70 days at P240 and… CONTINUE READING
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