Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF.

@article{Gpfert2003CellCT,
  title={Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF.},
  author={Ulrich G{\"o}pfert and Michael Kullmann and Ludger Hengst},
  journal={Human molecular genetics},
  year={2003},
  volume={12 14},
  pages={1767-79}
}
p27(Kip1) regulates cell proliferation by binding to and modulating the activity of cyclin-dependent kinases. The CDK inhibitor is haploinsufficient for tumor suppression and reduced p27 activity is fundamental for the development of many human malignancies. Consistently, reduced p27 protein provides independent prognostic information in various tumors including breast, prostate, colon and gastric carcinomas. In normal cells, p27 protein increases in growth arrest but also oscillates during… CONTINUE READING

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