Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes

@article{Wittenberg2005CellCT,
  title={Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes},
  author={Curt Wittenberg and S. I. Reed},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={2746-2755}
}
In the budding yeast, Saccharomyces cerevisiae, a significant fraction of genes (>10%) are transcribed with cell cycle periodicity. These genes encode critical cell cycle regulators as well as proteins with no direct connection to cell cycle functions. Cell cycle-regulated genes can be organized into ‘clusters’ exhibiting similar patterns of regulation. In most cases periodic transcription is achieved via both repressive and activating mechanisms. Fine-tuning appears to have evolved by the… CONTINUE READING