Cell cycle-dependent recruitment of HDAC-1 correlates with deacetylation of histone H4 on an Rb-E2F target promoter.

@article{Ferreira2001CellCR,
  title={Cell cycle-dependent recruitment of HDAC-1 correlates with deacetylation of histone H4 on an Rb-E2F target promoter.},
  author={Roger Daniel Francisco Ferreira and Irina Naguibneva and Marion Mathieu and Slimane Ait-Si-Ali and Philippe Robin and Linda Louise Pritchard and Annick Harel-Bellan},
  journal={EMBO reports},
  year={2001},
  volume={2 9},
  pages={794-9}
}
The transcription factor E2F, which is a key element in the control of cell proliferation, is repressed by Rb and other pocket proteins in growth-arrested differentiating cells, as well as in proliferating cells when they progress through early G1. It is not known whether similar mechanisms are operative in the two situations. A body of data suggests that E2F repression by pocket proteins involves class I histone deacetylases (HDACs). It has been hypothesized that these enzymes are recruited to… CONTINUE READING

From This Paper

Topics from this paper.
30 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…