Cell cycle-dependent proteolysis and phosphorylation of human Mcm10.

  title={Cell cycle-dependent proteolysis and phosphorylation of human Mcm10.},
  author={Masako Izumi and Fumio Yatagai and Fumio Hanaoka},
  journal={The Journal of biological chemistry},
  volume={276 51},
Mcm10 (Dna43) is an essential protein for chromosomal DNA replication in Saccharomyces cerevisiae. Recently, we identified a human Mcm10 homolog that interacts with the mammalian Orc2 and Mcm2-7 complex. We additionally demonstrated that human Mcm10 binds nuclease-resistant nuclear structures during S phase and dissociates from them in G(2) phase. In this study, we have further characterized the subcellular localization, modification, and expression levels of human Mcm10 protein throughout the… CONTINUE READING

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