Cell cycle-dependent phosphorylation of p27 cyclin-dependent kinase (Cdk) inhibitor by cyclin E/Cdk2.

@article{Morisaki1997CellCP,
  title={Cell cycle-dependent phosphorylation of p27 cyclin-dependent kinase (Cdk) inhibitor by cyclin E/Cdk2.},
  author={Hiroko Morisaki and Atsushi Fujimoto and Akira Ando and Yosuke Nagata and Kazuo Ikeda and Makoto Nakanishi},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={240 2},
  pages={386-90}
}
The cyclin-dependent kinase (Cdk) inhibitor p27 interrupts progression of the cell cycle by inhibiting various cyclin/Cdk activities. Since the protein level of p27 does not correlate with its mRNA level or protein synthesis rate in most cases, it is suggested that degradation of the protein may be regulated via an unidentified mechanism(s) involving a post-translational modification(s). We present evidence here that p27 phosphorylation is cell cycle-dependent and peaks in the late G1 phase and… CONTINUE READING