Cell cycle-dependent establishment of a late replication program.

@article{Raghuraman1997CellCE,
  title={Cell cycle-dependent establishment of a late replication program.},
  author={M. K. Raghuraman and Bonita J. Brewer and Walton L. Fangman},
  journal={Science},
  year={1997},
  volume={276 5313},
  pages={806-9}
}
DNA replication origins in chromosomes of eukaryotes are activated according to a temporal program. In the yeast Saccharomyces cerevisiae, activation of origins in early S phase appears to be a default state. However, cis-acting elements such as telomeres can delay origin activation until late S phase. Site-specific recombination was used to separate origin from telomere in vivo, thereby demonstrating that the signal for late activation is established between mitosis and START in the subsequent… CONTINUE READING

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