Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cells.

@article{Chinnakannu2009CellCE,
  title={Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cells.},
  author={Kannagi Chinnakannu and Di Chen and Yiwei Li and Zhiwei Wang and Q Ping Dou and G Prem Veer Reddy and Fazlul H. Sarkar},
  journal={Journal of cellular physiology},
  year={2009},
  volume={219 1},
  pages={94-9}
}
Epidemiological studies have shown that a diet rich in fruits and cruciferous vegetables is associated with a lower risk of prostate cancer. Indole-3-carbinol (I3C) and its dimeric product 3,3'-diindolylmethane (DIM) have been shown to exhibit anti-tumor activity both in vitro and in vivo. Recently, we have reported that a formulated DIM (B-DIM) induced apoptosis and inhibited growth, angiogenesis, and invasion of prostate cancer cells by regulating Akt, NF-kappaB, VEGF and the androgen… CONTINUE READING
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