Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains.

Abstract

Germ-line mutations of the BRCA1 gene predispose women to early-onset breast and ovarian cancer by compromising the gene's presumptive function as a tumor suppressor. Although the biochemical properties of BRCA1 polypeptides are not understood, their expression pattern and subcellular localization suggest a role in cell-cycle regulation. When resting cells… (More)

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@article{Jin1997CellCC, title={Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains.}, author={Y. Jin and X L Xu and Ming Chi Yang and Fan Wei and Teck Choon Ayi and Anne M. Bowcock and Richard J Baer}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1997}, volume={94 22}, pages={12075-80} }