Cell-cycle dependence of foamy virus vectors.

  title={Cell-cycle dependence of foamy virus vectors.},
  author={Gillian S. Patton and Otto Erlwein and Myra O. McClure},
  journal={The Journal of general virology},
  volume={85 Pt 10},
Retroviruses differ in the extent to which they are dependent on host-cell proliferation for their replication, an aspect of their replication that impacts on their vector potential. Foamy viruses offer distinct advantages over other retroviruses for development as vectors for gene therapy. A vector derived from the prototypic foamy virus (PFV), formerly known as human foamy virus (HFV), transduced aphidicolin-arrested cells five- to tenfold more efficiently than one derived from murine… CONTINUE READING

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