Cell cycle-dependence of HL-60 cell deformability.

  title={Cell cycle-dependence of HL-60 cell deformability.},
  author={Mientao A. Tsai and Richard E. Waugh and Peter C. Keng},
  journal={Biophysical journal},
  volume={70 4},
In this study, the role of cytoskeleton in HL-60 deformability during the cell cycle was investigated. G1, S, and G2/M cell fractions were separated by centrifugal elutriation. Cell deformability was evaluated by pipette aspiration. Tested at the same aspiration pressures, S cells were found to be less deformable than G1 cells. Moreover, HL-60 cells exhibited power-law fluid behavior: mu = mu c(gamma m/ gamma c)-b, where mu is cytoplasmic viscosity, gamma m is mean shear rate, mu c is the… CONTINUE READING

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