Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

@article{Campisi1984CellcycleCO,
  title={Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation},
  author={J. Campisi and H. E. Gray and A. Pardee and M. Dean and G. Sonenshein},
  journal={Cell},
  year={1984},
  volume={36},
  pages={241-247}
}
Cellular oncogenes are DNA sequences implicated in the genesis of cancer, but their functions in the transformation process are not understood. Our experiments provide data linking expression of two well-studied proto-oncogenes, c-myc and c-rasKi, to current knowledge of proliferation control and its perturbation by differentiation and chemical transformation. Growth stimulation of quiescent cells by serum elevates expression of the myc proto-oncogene in Balb/c 3T3 (A31) cells. In two… Expand
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