Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.

@article{Pauls2014CellCC,
  title={Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.},
  author={Eduardo Pauls and Alba Valdivia Ruiz and Roger Badia and Marc Permanyer and Albert Gubern and Eva Riveira-Mu{\~n}oz and Javier Torres-Torronteras and Mar Alvarez and Beatriz Mothe and Christian Brander and M O Pun{\'i}n Crespo and Luis Men{\'e}ndez-Arias and Bonaventura Clotet and Oliver T. Keppler and Ramon Mart{\'i} and Francesc Posas and Ester Ballana and Jos{\'e} A. Est{\'e}},
  journal={Journal of immunology},
  year={2014},
  volume={193 4},
  pages={
          1988-97
        }
}
Proliferating cells are preferentially susceptible to infection by retroviruses. Sterile α motif and HD domain-containing protein-1 (SAMHD1) is a recently described deoxynucleotide phosphohydrolase controlling the size of the intracellular deoxynucleotide triphosphate (dNTP) pool, a limiting factor for retroviral reverse transcription in noncycling cells. Proliferating (Ki67(+)) primary CD4(+) T cells or macrophages express a phosphorylated form of SAMHD1 that corresponds with susceptibility to… CONTINUE READING
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