Cell cycle control, checkpoint mechanisms, and genotoxic stress.

  title={Cell cycle control, checkpoint mechanisms, and genotoxic stress.},
  author={Rodney E. Shackelford and William K. Kaufmann and Richard S. Paules},
  journal={Environmental Health Perspectives},
  pages={5 - 24}
The ability of cells to maintain genomic integrity is vital for cell survival and proliferation. Lack of fidelity in DNA replication and maintenance can result in deleterious mutations leading to cell death or, in multicellular organisms, cancer. The purpose of this review is to discuss the known signal transduction pathways that regulate cell cycle progression and the mechanisms cells employ to insure DNA stability in the face of genotoxic stress. In particular, we focus on mammalian cell… CONTINUE READING