Cell cycle checkpoints: arresting progress in mitosis.

  title={Cell cycle checkpoints: arresting progress in mitosis.},
  author={Gary J Gorbsky},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={19 3},
  • Gary J Gorbsky
  • Published 1997 in
    BioEssays : news and reviews in molecular…
Cell cycle arrest in M phase can be induced by the failure of a single chromosome to attach properly to the mitotic spindle. The same cell cycle checkpoint mediates M phase arrest when cells are treated with drugs that either disrupt or hyperstabilize spindle microtubules. Study of yeast mutants that fail to arrest in the presence of microtubule disruptors identified a set of genes important in this checkpoint pathway. Two recent papers report the cloning of human and Xenopus homologues of one… CONTINUE READING

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