Cell cycle checkpoint proteins and cellular response to treatment by anticancer agents.

@article{Damia2004CellCC,
  title={Cell cycle checkpoint proteins and cellular response to treatment by anticancer agents.},
  author={Giovanna Damia and Massimo Broggini},
  journal={Cell cycle},
  year={2004},
  volume={3 1},
  pages={46-50}
}
The response of cancer cells to treatment with anticancer agents is mediated in part by proteins controlling both the cell cycle progression and the genomic integrity, including p53, p73 and checkpoint proteins chk1 and chk2. We here summarized the cellular functions of these proteins, their alterations in human tumors and the impact of their mutations/alterations on cellular response to treatment, Particular attention has been paid for those studies performed in isogenic cell systems, to… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…