Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells.

@article{Kaji2003CellCC,
  title={Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells.},
  author={Noriko Kaji and Kazumasa Ohashi and Mika Shuin and Ryusuke Niwa and Tadashi Uemura and Kensaku Mizuno},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 35},
  pages={33450-5}
}
During cytokinesis the actomyosin-based contractile ring is formed at the equator, constricted, and then disassembled prior to cell abscission. Cofilin stimulates actin filament disassembly and is implicated in the regulation of contractile ring dynamics. However, little is known about the mechanism controlling cofilin activity during cytokinesis. Cofilin is inactivated by phosphorylation on Ser-3 by LIM-kinase-1 (LIMK1) and is reactivated by a protein phosphatase Slingshot-1 (SSH1). Here we… CONTINUE READING

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