Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM

@inproceedings{Engeland2018CellCA,
  title={Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM},
  author={Kurt Engeland},
  booktitle={Cell Death and Differentiation},
  year={2018}
}
Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent years it has become evident that p53-dependent repression is controlled by the p53–p21–DREAM–E2F/CHR pathway (p53–DREAM pathway). DREAM is a transcriptional repressor that binds to E2F or CHR promoter sites. Gene regulation and deregulation by DREAM shares many mechanistic characteristics with the retinoblastoma pRB… CONTINUE READING

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