Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents.

@article{Poon1998CellCA,
  title={Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents.},
  author={Betty T M Poon and Kathie Grovit-Ferbas and Scott A Stewart and Irvin S. Y. Chen},
  journal={Science},
  year={1998},
  volume={281 5374},
  pages={266-9}
}
Expression of human immunodeficiency virus-type 1 (HIV-1) Vpr after productive infection of T cells induces cell cycle arrest in the G2 phase of the cell cycle. In the absence of de novo expression, HIV-1 Vpr packaged into virions still induced cell cycle arrest. Naturally noninfectious virus or virus rendered defective for infection by reverse transcriptase or protease inhibitors were capable of inducing Vpr-mediated cell cycle arrest. These results suggest a model whereby both infectious and… CONTINUE READING