Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3.

@article{EllingerZiegelbauer1999CellCA,
  title={Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3.},
  author={H Ellinger-Ziegelbauer and Kathleen Kelly and Ulrich K Siebenlist},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 5},
  pages={3857-68}
}
Signal-induced proliferation, differentiation, or stress responses of cells depend on mitogen-activated protein kinase (MAPK) cascades, the core modules of which consist of members of three successively acting kinase families (MAPK kinase kinase [MAP3K], MAPK kinase, and MAPK). It is demonstrated here that the MEKK3 kinase inhibits cell proliferation, a biologic response not commonly associated with members of the MAP3K family of kinases. A conditionally activated form of MEKK3 stably expressed… CONTINUE READING

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